Product and Process Engineering - Delft University of Technology

Pouyan Boukany

Pouyan Boukany

Contact details

  • Dr. Pouyan Boukany
  • Delft University of Technology, TNW-PPE
  • Room F2.450
  • van der Maasweg, 9, 2629 HZ, Delft,
  • Phone: +31-(0)15-27 89981
  • P.E.Boukany@tudelft.nl

Research interests

Selected publications (h-index:19)

  • Generating Aligned Micellar Nanowire Arrays by Dewetting of Micro-patterned Surfaces, P.J. Glazer, L. Bergen, L. Jennings, A. J. Houtepen, E. Mendes and Boukany, P.E.*,Small, 2014, 10, 1729-1734, (cover article) . DOI: 10.1002/smll.201303414.
  • Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation, Pouyan E. Boukany,* Wu, Y.,Zhao, X.,Kwak, K., Glazer, P., Leong, K., Lee, L.J., Advanced Healthcare Materials 2014, ,3, 682–689. (cover article) . DOI: 10.1002/adhm.201300213
  • Nanochannel electroporation delivers precise amounts of biomolecules into living cells, Pouyan E. Boukany, Andrew Morss, Wei-ching Liao, Brian Henslee, HyunChul Jung, Xulang Zhang, Bo Yu, Xinmei Wang, Yun Wu, Lei Li, Keliang Gao, Xin Hu, Xi Zhao, O. Hemminger, Wu Lu, Gregory P. Lafyatis, and L. James Lee. Nature Nanotech. 2011, 6, 747–754. DOI: 10.1038/nnano.2011.164
  • The large area of laterally ordered nanochannel arrays from DNA combing and imprinting, Jingjiao Guan, Pouyan E. Boukany, O. Hemminger, L. J. Lee,Adv. Mat. 2010, 22, 3997-4001. DOI: 10.1002/adma.201000136
  • Molecular Imaging of Slip in Entangled DNA Solution, Pouyan E. Boukany, O. Hemminger, Shi-Qing Wang, L. J. Lee, Phys. Rev. Lett. 2010, 105, 027802. DOI: 10.1103/PhysRevLett.105.027802
  • Shear banding or not in entangled DNA solutions, Pouyan E. Boukany and Shi-Qing, Wang, Macromolecules, 2010, 43, 6950. DOI: 10.1021/ma101267b

Education

  • Postdoc - Center for Affordable Nanoengineering of Polymeric Biomedical Devices, Ohio State University, Columbus, USA (1/2009-10/2011)
  • PhD - Polymer Science, University of Akron, Akron, USA (12/2008)
  • MSc - Chemical Engineering, Isfahan University of Technology, Iran (2002)

Awards and Grants

  • Delft Global Project, Getting HOT (collaboration with Eduardo Mendes, and Luigi Sasso), (2017-2021)
  • Van Gogh Grant (collaboration with Prof. Mounir Tarek in Université de Lorraine), (2015-2016)
  • European Research Council (ERC) Starting Grant (ERC-STG) (1.5 M€), (2014-2019)
  • Marie Curie-Career Integration Grant (CIG) (100 k€), (2013-2017)
  • NanoNextNL Grant-10C (150 k€),(2013-2015)
  • American Institute of Chemists Outstanding Postdoctoral Award, (Spring 2011)
  • 2nd place prize for Postdoctoral Research Competition in Society of Rheology, (Fall 2009)
  • Finalist for the Frank J. Padden Award for Excellence in Polymer Physics Research, (APS, spring 2008)
  • Finalist for the Bausch & Lomb Award for Innovative Research, (Summer 2008)
  • Travel Award for Society of Rheology,(Fall 2007)
  • University Scholarship, The University of Akron, Polymer Science Department (2004-2008)

Current Research

 

Current research schematic of Pouyan Boukany's research

We will use DNA as a nanotemplate to produce biochips for drug/gene delivery, bio-sensing and medical diagnostic applications and as a model to probe the dynamics of complex fluids. Our research objective is comprised of two main thrusts. The first one is devoted to use nanofluidics-based devices for providing quantitative insights into the fundamental mechanism of drug delivery, disease treatment, gene therapy and response of individual cells to therapeutic/biomolecular reagents. The second one is to understand the molecular dynamics of complex fluids using DNA as a model and advanced visualization techniques. Our interdisciplinary team will focus on new and exciting research in the following areas:

  • Nonviral gene therapy
  • DNA biophysics
  • Nanofluidics for Drug/Gene Delivery
  • Nano-chip devices for detection of biomolecules
  • Molecular rheology and rheo-physics

Given the multidisciplinary nature of our proposed research, I will actively seek collaborations with experimental/theoretical scientists in biology, chemistry, biophysics, and chemical engineering. Potential collaborators are encouraged to directly contact me at P.E.Boukany@TUDelft.nl

Cover Story:

Recent Publications:

  • 2017


    1. “Elastic instabilities during flow of hydrolyzed polyacrylamide solution in porous media: Effect of pore-shape and salt ”
      Durgesh Kawale, Esteban Marques,Pacelli Zitha, Michiel Kreutzer, William Rossen and Boukany, P.E.*
      Soft Matter, 13, 765-775 (2017).DOI: 10.1039/C6SM02199A.


    2. “Lipid vesicles in pulsed electric fields: fundamental principles of the membrane responses and its biomedical application ”
      Dayinta L. Perrier, Lea Rems, and Boukany, P.E.*
      Advances in Colloid and Interface Science, published online (2017). DOI: 10.1016/j.cis.2017.04.016.


    3. “Polymer conformation during flow in porous media ”
      Durgesh Kawale, Gelmer Bouwmen,Shaurya Sachdev, Pacelli Zitha, Michiel Kreutzer, William Rossen and Boukany, P.E.*
      Soft Matter, To be published (2017).


    4. “ Microscopic origin of wall slip during ow of an entangled DNA solution in microuidics: Flow induced chain stretching versus chain desorption”
      Orin Hemminger, and Boukany, P.E.*
      Biomicrofluidics, accepted (2017). DOI: 10.1063/1.4991496.


    5. “Stress relaxation in viscous soft spheres ”
      Julia Boschan,Siddarth A. Vasudevan, Boukany, P.E, Ellak Somfai, and Brian P. Tighe.
      Soft Matter, under review (2017).
  • 2016


    1. “Flow of DNA in micro/nano-fluidics: from fundamentals to applications ”
      Lea Rems, Durgesh Kawale, L. James Lee, and Boukany, P.E.*
      Biomicrofluidics,10, 043403(2016). DOI: 10.1063/1.4958719


    2. “Scaling of mixing time for droplets of different size traveling through a serpentine microchannel ”
      Yogesh M. Harshe, Michael J. van Eijk, Chris R. Kleijn Michiel T. Kreutzer,and Boukany, P.E.*
      RSC. ADV., 6,98812-98815 (2016). DOI: 10.1039/C6RA17728J


    3. “Molecular processes leading to necking in extensional flow of polymer solutions: using micro-fluidics and single DNA imaging ”
      Shaurya Sachdev, and Boukany, P.E.*
      Macromolecules, published online (2016).DOI: 10.1021/acs.macromol.6b01755


    4. “Induced Apoptosis Investigation in Wild-Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR ”
      Gao, Keliang; Huang, Xiaomeng; Wang, Xinmei; Chang, Lingqian; Chiang, Chi-Ling; Boukany, Pouyan; Marcucci, Guido; Lee, Robert; Lee, L. James
      Molecular Therapy, online (2016).DOI:10.1038/mt.2016.6
  • 2015


    1. “Shear Banding in Entangled Polymers in Micron Scale Gap: a Confocal-Rheoscopic Study ”
      Boukany, P.E.,* Wang, S.Q.,S. Ravindranath, and L. J. Lee
      Soft Matter, 11 (2015), 8058-8068. ( feastured as Back Cover) DOI:10.1039/C5SM01429H [Impact 4.1]


    2. “Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia ”
      X. Zhao, X. Huang, X. Wang, Y. Wu, A. Eisfeld, S. Schwind, D. Gallego-Perez, Boukany, P.E., G. I. Marcucci, L. J. Lee*
      Advanced Science, published online (2015). DOI:10.1002/advs.201500111.


    3. “Affordable techniques for fabricating large array of functional nanowires: From DNA to micellar systems”
      P.J. Glazer, Q Warringa, L Bergen, P. E. Boukany*
      IEE (EMBC) 2187-2190 (2015). DOI:10.1109/EMBC.2015.7318824.
  • 2014


    1. “Generating Aligned Micellar Nanowire Arrays by Dewetting of Micro-patterned Surfaces ”
      P.J. Glazer, L. Bergen, L. Jennings, A. J. Houtepen, E. Mendes and Boukany, P.E.,*
      Small, 10 (2014),1729-1734.(Cover article) DOI: 10.1002/smll.201303414. [Impact 7.5]



    2. “Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation”
      Boukany, P.E.,* Wu, Y.,Zhao, X.,Kwak, K., Glazer, P., Leong, K., Lee, L.J.,
      Advanced Healthcare Materials, 3 (2014), 682–689. (Cover article) DOI:10.1002/adhm.201300213. [Impact 5.8]
      (highlighted in MaterialsViews)


    3. “Letter to the Editor: Sufficiently entangled polymers do show shear strain localization at high enough Weissenberg numbers ” Wang,S.Q., G. Liu, S Cheng,
      Boukany, P.E, Y Wang, X. Li,
      Journal of Rheology, 58 (2014), 1059. DOI:10.1122/1.4884361. [Impact 3.2]

    Teaching

    • Reactors and Kinetics (MSc, CH3681)
    • Soft Matter for Chemical Products (MSc, CH3372a)
    • Thermodynamics and Transport Phenomena (BSc, NB2011)

    Funding

     

    Last Updated-July/20/2017


 
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