Product and Process Engineering - Delft University of Technology

Pouyan Boukany

Pouyan Boukany

Contact details

  • Dr. Pouyan Boukany
  • Delft University of Technology, TNW-PPE
  • Room F2.450
  • van der Maasweg, 9, 2629 HZ, Delft,
  • Phone: +31-(0)15-27 89981
  • P.E.Boukany@tudelft.nl

Research interests

Selected publications (h-index:18)

  • Generating Aligned Micellar Nanowire Arrays by Dewetting of Micro-patterned Surfaces, P.J. Glazer, L. Bergen, L. Jennings, A. J. Houtepen, E. Mendes and Boukany, P.E.*,Small, 2014, 10, 1729-1734, (cover article) . DOI: 10.1002/smll.201303414.
  • Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation, Pouyan E. Boukany,* Wu, Y.,Zhao, X.,Kwak, K., Glazer, P., Leong, K., Lee, L.J., Advanced Healthcare Materials 2014, ,3, 682–689. (cover article) . DOI: 10.1002/adhm.201300213
  • Nanochannel electroporation delivers precise amounts of biomolecules into living cells, Pouyan E. Boukany, Andrew Morss, Wei-ching Liao, Brian Henslee, HyunChul Jung, Xulang Zhang, Bo Yu, Xinmei Wang, Yun Wu, Lei Li, Keliang Gao, Xin Hu, Xi Zhao, O. Hemminger, Wu Lu, Gregory P. Lafyatis, and L. James Lee. Nature Nanotech. 2011, 6, 747–754. DOI: 10.1038/nnano.2011.164
  • The large area of laterally ordered nanochannel arrays from DNA combing and imprinting, Jingjiao Guan, Pouyan E. Boukany, O. Hemminger, L. J. Lee,Adv. Mat. 2010, 22, 3997-4001. DOI: 10.1002/adma.201000136
  • Molecular Imaging of Slip in Entangled DNA Solution, Pouyan E. Boukany, O. Hemminger, Shi-Qing Wang, L. J. Lee, Phys. Rev. Lett. 2010, 105, 027802. DOI: 10.1103/PhysRevLett.105.027802
  • Shear banding or not in entangled DNA solutions, Pouyan E. Boukany and Shi-Qing, Wang, Macromolecules, 2010, 43, 6950. DOI: 10.1021/ma101267b

Education

  • Postdoc - Center for Affordable Nanoengineering of Polymeric Biomedical Devices, Ohio State University, Columbus, USA (1/2009-10/2011)
  • PhD - Polymer Science, University of Akron, Akron, USA (12/2008)
  • MSc - Chemical Engineering, Isfahan University of Technology, Iran (2002)

Awards and Grants

  • Delft Global Project, Getting HOT (collaboration with Eduardo Mendes, and Luigi Sasso), (2017-2021)
  • Van Gogh Grant (collaboration with Prof. Mounir Tarek in Université de Lorraine), (2015-2016)
  • European Research Council (ERC) Starting Grant (ERC-STG) (1.5 M€), (2014-2019)
  • Marie Curie-Career Integration Grant (CIG) (100 k€), (2013-2017)
  • NanoNextNL Grant-10C (150 k€),(2013-2015)
  • American Institute of Chemists Outstanding Postdoctoral Award, (Spring 2011)
  • 2nd place prize for Postdoctoral Research Competition in Society of Rheology, (Fall 2009)
  • Finalist for the Frank J. Padden Award for Excellence in Polymer Physics Research, (APS, spring 2008)
  • Finalist for the Bausch & Lomb Award for Innovative Research, (Summer 2008)
  • Travel Award for Society of Rheology,(Fall 2007)
  • University Scholarship, The University of Akron, Polymer Science Department (2004-2008)

Current Research

 

Current research schematic of Pouyan Boukany's research

We will use DNA as a nanotemplate to produce biochips for drug/gene delivery, bio-sensing and medical diagnostic applications and as a model to probe the dynamics of complex fluids. Our research objective is comprised of two main thrusts. The first one is devoted to use nanofluidics-based devices for providing quantitative insights into the fundamental mechanism of drug delivery, disease treatment, gene therapy and response of individual cells to therapeutic/biomolecular reagents. The second one is to understand the molecular dynamics of complex fluids using DNA as a model and advanced visualization techniques. Our interdisciplinary team will focus on new and exciting research in the following areas:

  • Nonviral gene therapy
  • DNA biophysics
  • Nanofluidics for Drug/Gene Delivery
  • Nano-chip devices for detection of biomolecules
  • Molecular rheology and rheo-physics

Given the multidisciplinary nature of our proposed research, I will actively seek collaborations with experimental/theoretical scientists in biology, chemistry, biophysics, and chemical engineering. Potential collaborators are encouraged to directly contact me at P.E.Boukany@TUDelft.nl

Student projects

  • DNA transport through a nanochannel
  • Single-Molecule Imaging of DNA during flow/shear
  • Nano-electroporation for gene delivery

Highly motivated students interested in conducting exciting and rewarding projects are encouraged to contact me at P.E.Boukany@TUDelft.nl

Cover Story:

Full Publication Records:

  • 2017


    1. “Elastic instabilities during flow of hydrolyzed polyacrylamide solution in porous media: Effect of pore-shape and salt ”
      Durgesh Kawale, Esteban Marques,Pacelli Zitha, Michiel Kreutzer, William Rossen and Boukany, P.E.*
      Soft Matter, 13, 765-775 (2017).DOI: 10.1039/C6SM02199A.


    2. “Lipid vesicles in pulsed electric fields: fundamental principles of the membrane responses and its biomedical application ”
      Dayinta L. Perrier, Lea Rems, and Boukany, P.E.*
      Advances in Colloid and Interface Science, published online (2017). DOI: 10.1016/j.cis.2017.04.016.
  • 2016


    1. “Flow of DNA in micro/nano-fluidics: from fundamentals to applications ”
      Lea Rems, Durgesh Kawale, L. James Lee, and Boukany, P.E.*
      Biomicrofluidics,10, 043403(2016). DOI: 10.1063/1.4958719


    2. “Scaling of mixing time for droplets of different size traveling through a serpentine microchannel ”
      Yogesh M. Harshe, Michael J. van Eijk, Chris R. Kleijn Michiel T. Kreutzer,and Boukany, P.E.*
      RSC. ADV., 6,98812-98815 (2016). DOI: 10.1039/C6RA17728J


    3. “Molecular processes leading to necking in extensional flow of polymer solutions: using micro-fluidics and single DNA imaging ”
      Shaurya Sachdev, and Boukany, P.E.*
      Macromolecules, published online (2016).DOI: 10.1021/acs.macromol.6b01755


    4. “Induced Apoptosis Investigation in Wild-Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR ”
      Gao, Keliang; Huang, Xiaomeng; Wang, Xinmei; Chang, Lingqian; Chiang, Chi-Ling; Boukany, Pouyan; Marcucci, Guido; Lee, Robert; Lee, L. James
      Molecular Therapy, online (2016).DOI:10.1038/mt.2016.6


    5. “Stress Relaxation of Jammed Emulsions ”
      Siddarth A. Vasudevan, Julia Boschan, Daniel Bonn, Ellak Somfai, Brian P. Tighe, and Boukany, P.E.*
      Journal of Physics Condensed Matter, to be submitted (2016).
  • 2015


    1. “Shear Banding in Entangled Polymers in Micron Scale Gap: a Confocal-Rheoscopic Study ”
      Boukany, P.E.,* Wang, S.Q.,S. Ravindranath, and L. J. Lee
      Soft Matter, 11 (2015), 8058-8068. ( feastured as Back Cover) DOI:10.1039/C5SM01429H [Impact 4.1]


    2. “Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia ”
      X. Zhao, X. Huang, X. Wang, Y. Wu, A. Eisfeld, S. Schwind, D. Gallego-Perez, Boukany, P.E., G. I. Marcucci, L. J. Lee*
      Advanced Science, published online (2015). DOI:10.1002/advs.201500111.


    3. “Affordable techniques for fabricating large array of functional nanowires: From DNA to micellar systems”
      P.J. Glazer, Q Warringa, L Bergen, P. E. Boukany*
      IEE (EMBC) 2187-2190 (2015). DOI:10.1109/EMBC.2015.7318824.
  • 2014


    1. “Generating Aligned Micellar Nanowire Arrays by Dewetting of Micro-patterned Surfaces ”
      P.J. Glazer, L. Bergen, L. Jennings, A. J. Houtepen, E. Mendes and Boukany, P.E.,*
      Small, 10 (2014),1729-1734.(Cover article) DOI: 10.1002/smll.201303414. [Impact 7.5]



    2. “Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation”
      Boukany, P.E.,* Wu, Y.,Zhao, X.,Kwak, K., Glazer, P., Leong, K., Lee, L.J.,
      Advanced Healthcare Materials, 3 (2014), 682–689. (Cover article) DOI:10.1002/adhm.201300213. [Impact 5.8]
      (highlighted in MaterialsViews)


    3. “Letter to the Editor: Sufficiently entangled polymers do show shear strain localization at high enough Weissenberg numbers ” Wang,S.Q., G. Liu, S Cheng,
      Boukany, P.E, Y Wang, X. Li,
      Journal of Rheology, 58 (2014), 1059. DOI:10.1122/1.4884361. [Impact 3.2]

  • 2012


  1. “Letter to the Editor: Cone partitioned plate (CPP) vs circular couette”
    Ravindranath, S., Wang, Y., Boukany, P., , and Li, X.,
    Journal of Rheology, 56 (2012), 675. DOI:0.1122/1.4708515.

  • 2011


  1. “Nanochannel electroporation delivers precise amount of biomolecules into living cells”
    Boukany, P. E., Mross, A., Zhang, X., Bo, Y., Henslee, B., Wang, X. Wu, Y., Lafyatis, G., Lee, L. J.
    Nature Nanotech 6 (2011), 747. DOI:10.1038/nnano.2011.164. [Impact 30]
    (highlighted in Nature Methods, 2011, 8,996-997)




  2. “The use of microfluidics in rheology”
    Hu, X.; Boukany, P. E.; Hemminger, O.; Lee, L. J.
    Macromol. Mater. Eng 296 (2011), 308.
    DOI:10.1002/mame.201000246


  3. “Direct-write femtosecond laser ablation and DNA combing and imprinting for fabrication of a micro/nanofluidic device on an ethylene glycol dimethacrylate polymer”
    Lim,Y.; Boukany, P. E.; Farson, D.; Lee, L. J.
    J. Micromech. Microeng 21 (2011), 015012.
    DOI:10.1088/0960-1317/21/1/015012


  4. “Homogenous shear, wall slip and shear banding of entangled polymeric liquids in simple-shear rheometry: a road Map of non-linear rheology”
    Wang,S.Q., Ravindranath, S., Boukany, P. E.
    Macromolecules 44 (2011), 183.
    DOI:10.1021/ma101223q  [Impact: 4.8]
  • 2010


  1. “Flow pattern and molecular visualization of DNA solutions through a 4:1 planar micro-contraction”
    Hemminger,O.; Boukany, P. E.;* Wang, S. Q.; Lee, L. J.
    J. Non-Newtonian Fluids. 165 (2010), 1613.
    DOI:10.1016/j.jnnfm.2010.08.009


  2. “The large area of laterally ordered nanochannel arrays from DNA combing and imprinting”
    Guan,J.; Boukany, P. E.; Chiou, N.; Hemminger, O.; Lee, L. J.
    Advanced Materials 22 (2010), 3397.
    DOI:10.1002/adma.201000136 [Impact: 14]


  3. “Shear banding or not in entangled DNA solutions”
    Boukany, P. E.; Wang, S. Q. .
    Macromolecules 43 (2010), 6950.
    DOI:10.1021/ma101267b [Impact: 5.4]


  4. “Nanoimprinting using self assembled ceramic nanoislands&”
    Zimmerman,L. B.; Rauscher, M. D.; Ellis, J.; Boukany, P. E.; Lee, L. J.
    Nanotechnology 21 (2010), 045304.
    DOI:10.1088/0957-4484/21/4/045304 [Impact: 3.7]


  5. “ The molecular imaging of slip in entangled DNA solution ”
    Boukany, P.E Hemminger, O.; Wang, S. Q.; Lee, L. J ,
    Phys. Rev. Lett.105 (2010), 027802. [editor’s suggestions]
    DOI:10.1103/PhysRevLett.105.027802 [Impact 7.6]
  • 2009
  1. Boukany, P. E.; Wang, S. Q. “Nature of steady flow in entangled fluids revealed by super imposed oscillatory shear” J. Rheol.  (2009)53, 1403. [Impact 3.1]
  2. Boukany, P. E.; Wang, S. Q.; Wang, X. “Step shear of entangled linear polymer melts: New experimental evidence for elastic yielding” Macromolecules (2009) 42, 6261. [Impact:4.8]
  3. Boukany, P. E.; Wang, S. Q.; Wang, X. “Universal scaling behavior of startup shear of entangled linear polymer melts” J. Rheol. (2009) 53, 617. [Impact:3.1]
  4. Boukany, P. E.; Wang, S. Q. “Exploring the origin of interfacial yielding during and after shear” Macromolecules (2009) 42, 2222.[Impact:4.8]
  5. Boukany, P. E.; Wang, S. Q. “Exploring transition from wall slip to bulk shearing banding in well-entangled DNA solutions” Soft Matter (2009) 5, 780. [Impact:4.5]
  6. Boukany, P. E.; Wang, S. Q. “Shear banding or not in entangled DNA solutions depending on the level of entanglement” J. Rheol. (2009) 53, 73. [Impact:3.1]
  • 2008
  1. Boukany, P. E.; Hu, Y. T.; Wang, S. Q. “Observations of wall slip and shear banding in an entangled DNA solution” Macromolecules (2008) 41, 2644. [Impact:4.8]
  2. Boukany, P. E.; Wang, S. Q. “Use particle tracking velocimetry and flow birefringence to study nonlinear flow behavior of entangled worm-like micellar solutions: From wall slip to bulk disentanglement and chain scission” Macromolecules (2008) 41, 1455.[Impact:4.8]
  • 2007
  1. Wang,Y.; Boukany, P. E.; Wang, S. Q.; Wang, X. “Elastic breakup in uniaxial extension of entangled polymer melts” Phys. Rev. Lett. (2007) 99, 237801. [Impact:7.6]
  2. Wang, S. Q.; Rvindranath, S.; Wang, Y.; Boukany, P. E.; “New theoretical consideration in polymer rheology: Elastic breakdown of chain entanglement network” J. Chem. Phys. (2007) 127, 064903.[Impact:3.1]
  3. Boukany, P. E.; Wang, S. Q. “A correlation between velocity profile and molecular weight distribution in sheared entangled polymer solutions” J. Rheol. (2007) 51, 217. [Impact:3.1]
  • 2006
  1. Wang,S. Q.; Rvindranath, S.; Boukany, P. E.; Olechnowics, M.; Quirk, R. P.; Halasa, A.; Mays, J. “Non-quiescent relaxation in entangled polymeric liquids after step shear” Phys. Rev. Lett. (2006) 97, 187801. [Impact:7.6]
  2. Boukany, P. E.; Tapadia, P.; Wang, S. Q. “Interfacial stick-slip transition in simple shear of entangled melts” J. Rheol. (2006), 50, 641. [Impact:3.1]

Teaching

  • Reactors and Kinetics (MSc, CH3681)
  • Soft Matter for Chemical Products (MSc, CH3372a)
  • Thermodynamics and Transport Phenomena (BSc, NB2011)

Funding

 

Last Updated-July/20/2015


 
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