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Simulations of Magnetic Capturing of Drug Carriers in the Brain Vascular System

Simulations of Magnetic Capturing of Drug Carriers in the Brain Vascular System, S. Kenjeres and B. W. Righolt. International Journal of Heat and Fluid Flow 2012, 35  (SI), 68–75.

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Abstract

The present paper reports on numerical simulations of blood flow and magnetic drug carrier distributions in a complex brain vascular system. The blood is represented as a non-Newtonian fluid by the generalised power law. The Lagrangian tracking of the double-layer spherical particles is performed to estimate particle deposition under influence of imposed magnetic field gradients across arterial walls. Two situations are considered: neutral (magnetic field off) and active control (magnetic field on) case. The double-layer spherical particles that mimic a real medical drug are characterised by two characteristic diameters - the outer one and the inner one of the magnetic core. A numerical mesh of the brain vascular system consisting of multi-branching arteries is generated from raw MRI scan images of a patient. The blood is supplied through four main inlet arteries and the entire vascular system includes more than 30 outlets, which are modelled by Murray's law. The no-slip boundary condition is applied for velocity components along the smooth and rigid arterial walls. Numerical simulations revealed detailed insights into blood flow patterns, wall-shear-stress and local particle deposition efficiency along arterial walls. It is demonstrated that magnetically targeted drug delivery significantly increased the particle capturing efficiency in the pre-defined regions. This feature can be potentially useful for localised, non-invasive treatment of brain tumours. (C) 2012 Elsevier Inc. All rights reserved.

BibTeX

@article{ ISI:000306351400009,
Author = {Kenjeres, S. and Righolt, B. W.},
Title = {Simulations of Magnetic Capturing of Drug Carriers in the Brain Vascular System},
Journal = {International Journal of Heat and Fluid Flow},
Year = {2012},
Volume = {35},
Number = {SI},
Pages = {68-75},
Month = {},
Note = {},
Abstract = {The present paper reports on numerical simulations of blood flow and magnetic drug carrier distributions in a complex brain vascular system. The blood is represented as a non-Newtonian fluid by the generalised power law. The Lagrangian tracking of the double-layer spherical particles is performed to estimate particle deposition under influence of imposed magnetic field gradients across arterial walls. Two situations are considered: neutral (magnetic field off) and active control (magnetic field on) case. The double-layer spherical particles that mimic a real medical drug are characterised by two characteristic diameters - the outer one and the inner one of the magnetic core. A numerical mesh of the brain vascular system consisting of multi-branching arteries is generated from raw MRI scan images of a patient. The blood is supplied through four main inlet arteries and the entire vascular system includes more than 30 outlets, which are modelled by Murray's law. The no-slip boundary condition is applied for velocity components along the smooth and rigid arterial walls. Numerical simulations revealed detailed insights into blood flow patterns, wall-shear-stress and local particle deposition efficiency along arterial walls. It is demonstrated that magnetically targeted drug delivery significantly increased the particle capturing efficiency in the pre-defined regions. This feature can be potentially useful for localised, non-invasive treatment of brain tumours. (C) 2012 Elsevier Inc. All rights reserved.},
DOI = {10.1016/j.ijheatfluidflow.2012.03.008},
ISSN = {0142-727X},
ResearcherID-Numbers = {Kenjeres, Sasa/A-2064-2011},
Unique-ID = {ISI:000306351400009},
}

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